26 August, 2014

Ebola virus, Can Chinese medicine be more effective? (Revised)


The pathology:  The particle consists of a genome wrapped up in two layers of protein. When the virus infects a cell the polymerase makes copies of genome and the cells is tricked into using these to make the proteins that the virus needs. Particularly, VP35 and VP24 prevent interferon, a class of molecule that alerts the immune system from being made. The sugars on the virus’s outside make it hard for other parts of the immune system to get to grips with; the virus makes infected cells produce more glycoprotein than it needs for its coats, with the surplus simply secreted into the bloodstream. Antibodies which would otherwise attack the virus stick to this decoy protein instead.


Immune cells which the virus attacks in the bloodstream early on carry attacks in the blood stream early on carry the infection to the liver, the spleen, and lymph nodes. Symptoms may manifest themselves in a day or two or may wait weeks. Eventually the virus’s spread triggers an immune overreaction known as a cytokine storm. Blood vessel walls become leaky, blood pressure and core temperature drop, organs fail and the body goes into shock. Some of the sick weather the storm, but most who survive infection do so by never getting to its direst straits. Some do not succumb at all. Some infected but never fallen ill.

The epitome of Ebola symptoms: Ebola’s patient can feel like the flu or other illnesses. Symptoms show up 2 to 21 days after infection and usually include:

•           High fever

•           Headache

•           Joint and muscle aches

•           Sore throat

•           Weakness

•           Stomach pain

•           Lack of appetite

As the disease gets worse, it causes bleeding inside the body, as well as from the eyes, ears, and nose.  Some people will vomit or cough blood, have bloody diarrhoea, and get a rash.
In Chinese Medicine theory, it is categorized as 热毒疫Bleeding is corresponding to the theory of 热入血分, 迫血妄行  (heat invaded the blood phase, forcing blood off course).  TCM diagnoses it as a combination of  endotoxin derived from heat(热毒), internal stasis of dampness heat湿热, blood stasis血瘀 ;As the virus attacks immune system, particularly, It further weaken spleen and kidney, in TCM terms, resulting deficiency in Yin and Yang阴阳两虚. The following prescription is in accordance with the rules of treatment of the diagnosis above:

鲜马齿苋1 (Fresh Purslane herb)   川黄连5(Golden thread)    生大黄3钱(后下)(Rhubarb)制附子3 (Prepared common monkshood daughter root))  硫黄2 (Sulfur)   灶心土1 (Furnace Soil)     川厚朴3 (Officinal magnolia bark)    佩兰3(Fortune eupatorium herb)   乌梅6  (Smoked plum)   肉豆蔻3   (Semen Myristicae)   漂白术5 (Largehead Astractylodes Rhizome)    淮山药5   (Common yam rhizome)  京赤芍3 (Red Peony root)     淡干姜3 (Zingiber Dried Ginger)     粉葛根5   (Kudzuvine Root) 单桃仁3 (Peach seed)      晚蚕砂3 (Silkworm Shit)    东阿胶5 (烊化)(Gelatin)( melting by heat)    牡丹皮3   (Tree peony bark)   净连翘5 (Weeping forsythia capsule)   杭白芍 6 ,(White peony root)

I posted the prescription on social media, but was given short shrift and brushed aside. I think there are several reasons for what happens the way it is.

One, we all pedestal authority, worship mainstream institution preponderantly as beyond doubt, other non-mainstream sources are slighted.

Two, culture differences on taking risk: The American culture to taking drug (Medicine) is more conservative; prefer FDA approval by rigorously tested and yielding positive results. It is good, but comes at a high price.

Three, the prevalent trends is towards discovery of new vaccine, seeing this path as the only way out of taming the epidemic.

There is nothing egregiously bad for the reasons I mentioned. It is all about choices we have, and the circumstances we are in. For example, WHO allowed untested drug for use, it is the circumstances determine the choices at hand and calibrated a seemingly unethical decision hopefully to ameliorate the situation.

We makes grave mistake without spanning the full gamut if we are obstinate to rule out every possibility of finding viable solution passing through the crucible.  This can happen to us because we have little knowledge of certain treatments; we have warped opinion of it, we disregard every avenue in the experiments in the discovery process. All those are not science. Many of the time, these kinds of behavioural distortions imbue our thinking; it becomes hindrance to great discovery due to our ignorance.

Why I think my prescription worth a second look?

It is a credible choice among current treatments. Mainstream medical treatments have yet come out with anything proclaimed efficacious; it is worth spending the resources on something may serendipitously cut the mustard.

The solution is relatively cheap and affordable to many Africans compared to many Western drugs.

At present, there is an ethical conundrum that too many patients chasing for paucity of unproven drugs available. To whom are to give first? (The situation may change soon, but most vaccine are untested) With this prescription, there is a ready source of supplies to go round for all patients. Restriction of human movements is futile to resolve the root cause but just control the spread and it elicits incessant other social and economic problems, It is hell-bent to quickly finding an efficacious solution,  key to preventing things run amok.


I don’t claim it is hundred per cent efficacious, there is no perfect drug even proven by authority, those who study medicine probably assent to this point. Much of the drawing from this prescription is: it is based on thousand years of empirical experiments and also I have no skin in the game.